| خلاصه مقاله | Wound and ulcer healing are one of the major clinical problems that have great impact at personal, professional and social levels, with high cost for treatment. According to available treatments, there is still no definitive and sufficient cure for chronic wounds. Physiologically, after injury, Platelets localize in wound or ulcer site and stimulate cell migration, wound healing and tissue repair by secreting growth factors and cytokines. Therefore, hemoderivative material such as Platelet rich plasma (PRP), Platelet rich fibrin (PRF) and Platelet gel (PG) are used to treat wounds. The new hemoderivative material which used today to tissue healing is platelet lysate. It contains more platelet-derived growth factors than other hemoderivative material materials and, unlike other hemoderivative material, does not have platelet membranes and leukocytes and can be stored at temperatures below -20 ° C for a long time. Platelets have been used to heal wounds individually or in loaded with a variety of bioactive scaffolds and bioactive dresses such as fibrin-based scaffold and Collagen/Gelatin Scaffold. Growth factors such as PDGF, VEGF, and FGF have caused angiogenesis, migration and proliferation of epithelial cells and fibroblasts, extracellular matrix remodeling, nerve repair, reduce inflammation and consequently wound healing and tissue repair. Platelet lysates with high growth factor levels are a suitable material for wound healing and nerve tissue repair, however, this product should be used with caution so that its growth factors do not cause abnormal proliferation at the wound site. |