چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background and objectives: The aerial parts of Artemisia marschalliana Sprengel as an indigenous species of genus Artemisia in the East Azerbaijan province of Iran, was subjected to phytochemical analysis, as well as anti-proliferative, free-radical-scavenging and anti-malarial activities. Methods: The chemical composition of the essential oil obtained from the aerial parts of A. marschalliana was analyzed by GC/MS (gas chromatography/mass spectrometry) and GC/FID (gas chromatography/ flame ionization detector). The anti-proliferative, anti-oxidant, and anti-malarial activities of the essential oil were assessed by MTT, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and cell-free β-hematin formation assays, respectively. Results: A total of 38 constituents were identified, which represented 95.55% of the oil. The essential oil was characterized by a high content of oxygenated sesquiterpenes. The major components of the oil were spathulenol (38.25%), isoaromadendrene epoxide (8.5%), and caryophyllene oxide (7.31%). The oil exhibited cytotoxic activity against the human breast adenocarcinoma (MCF-7) cell line. The half maximal inhibitory concentration (IC50) of anti-malarial assay was 0.38±0.04 mg/mL; the oil, however, displayed low anti-oxidant activity. Conclusion: These findings will be beneficial for the further development of new chemotherapeutic or antimalarial agents. |
| نویسنده | نفر چندم مقاله |
|---|---|
| پرینا اصغریان | اول |
| معصومه زاده کمند | دوم |
| عباس دل آذر | سوم |
| سولماز اثناعشری | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| RJP_Volume 6_Issue 4_Pages 71-77.pdf | 1398/09/02 | 555474 | دانلود |
