چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| genes are one of the most important risk factors in BC. The aim of this study was to investigate the association of rs1946518 C/A polymorphism in the promoter region of the IL-18 gene and BC risk in Iranian women. In this case-control study, we recruited 140 women with BC as a case group and 140 age and ethnically matched women as healthy controls from East Azerbaijan, Tabriz in Iran. The genomic DNA was extracted using a salting-out method from peripheral blood leukocytes. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotype distribution in BC patients was 37.86% CC, 47.14% CA, and 15.00% AA, whereas in healthy controls these were 40.72% CC, 42.85% CA, and 16.43% AA. Statistical analysis showed that the genotype and allele frequencies of IL-18 rs1946518 C/A polymorphism were not significantly different between BC patients and healthy controls (p>0.05). The only significant difference between cases and controls was related to family history (p=0.023). In conclusion, our study indicated that IL-18 rs1946518 C/A polymorphism was not associated with BC in the Iranian women population. However, more studies on different races and geographic areas are required to determine the exact role of rs1946518 C/A polymorphism in prognosis, diagnosis, and risk of BC. Keywords: Breast cancer; Interleukin 18; Polymorphism Corresponding Author: Behzad Baradaran, PhD; Immunology Research Center, Tabriz University of Medical Sciences, Gholghasht Ave, |
| نویسنده | نفر چندم مقاله |
|---|---|
| نازیلا فتحی معروفی | اول |
| علیرضا عیسی زاده | هشتم |
| بهزاد برادران | یازدهم |
| صبا حاج عظیمیان | هفتم |
| سینا طائفه شکر | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 350-Association of rs1946518 C A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women.pdf | 1399/01/31 | 482851 | دانلود |
