چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Multiple sclerosis is a common neuroinflammatory disease of the central nervous system causing nervous system defects and severe physical disability. IL-21 is a proinflammatory cytokine produced mainly by Th-17 and Tfh cells which its exact role in MS was not yet clearly understood. In the present study we aimed to investigate the possible correlation of IL-21 gene expression, methylation, and its serum levels with MS severity and progression. The results showed that IL- 21 mRNA level and serum level were significantly increased in patient group compared with control group (p=0.02 and p<0.0001 respectively). Moreover, we found a strong positive correlation between IL-21 mRNA levels and EDSS scores (r=0.637, P<0.0001), IL-21 mRNA levels and Progression Index (r=0.540, P<0.0001), IL-21 serum levels and EDSS scores (r=0.617, P<0.0001), and IL-21 serum levels and Progression Index (r=0.527, P<0.0001) in MS patients. Additionally, we found that the methylation level of IL-21 promoter region was decreased in patient group compared with the control group (p< 0.0001). We also found that methylation level of IL-21 gene promoter is negatively correlated with the IL-21 mRNA level (r= -0.263, p= 0.02), serum level (r= -0.249, p= 0.03), EDSS scores (r= -0.276, p= 0.01) and Progression Index (r= -0.430, p= 0.0001). Data showed that the increased percentages of IL-21-producing Tfh-like, Th-17 and Th1 cells in patients are positively correlated with MS severity and progression. The results of our study suggest a proinflammatory and booster role for IL-21 in the MS pathogenesis and progression. |
| نویسنده | نفر چندم مقاله |
|---|---|
| توحید غریبی | اول |
| آرزو حسینی | دوم |
| فاروق معروفی | سوم |
| زهره بابالو | دهم |
| بهزاد برادران | یازدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| rezayatnamed.jpg | 1399/07/16 | 202278 | دانلود |
| 344-IL-21 and IL-21-producing T cells are involved in multiple sclerosis.pdf | 1398/09/18 | 1350499 | دانلود |
