چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Incomplete delivery of drugs to the cancerous tissue and the drug resistance mechanisms limit the medical applications of anticancer drugs. Colloidal systems offers many advantages owing to the non-invasive way of drug administration as well as centralized delivery of anti-cancer drugs to tumor tissue. Nanogels (Ngs) as a part of these colloidal systems have a good perspective for their ability to incorporate and encapsulate low-molecularmass drugs, bio-macromolecules, and proteins. Therefore, we developed pH and redox-responsive Ngs to provide a hopeful prospect for targeted delivery of anti-cancer drugs in cancer cells. For this purpose, chitosan (CS) was first modified with a chain transfer agent (CTA) and then, the polymerization of 2-Hydroxyethyl methacrylate (HEMA) monomer occurred to create (CTS-g-PHEMA). Hydroxyl groups of HEMA reacted with maleic anhydride molecules to prepare CTS-g-PHEMA-maleic acid (MAc). Finally, the double bonds of MAc were used for the grafting of N, N′ bis(acryloyl) cystamine (BAC) as a crosslinker agent to prepare redox-sensitive Ngs. The biocompatibility, chemical structures, DOX loading capacity, content of the drug released and in-vitro cytotoxicity effects were also studied. As a result, it is expected that Ngs can be applied as a potential nanomedicine carrier for the treatment of cancer. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مرجان قربانی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Ghorbani, 2019, 45.pdf | 1398/09/12 | 2946971 | دانلود |
