چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدی احمدی | اول |
| رعنا کیهان منش | دوم |
| رضا رهبرقاضی | سوم |
| حسین حیران | چهارم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Asthma, Conditioned media, Tracheal responsiveness, pathological scores |
| خلاصه مقاله | Abstract Background and Objective: It has been showed that systemic transplantation of MSC-CM could protect the lung architecture against inflammation. In contrary, we recently reported that systemic administration of MSC–CM in single dose has inert effects on IFN-γ/IL-4 balance in lung tissues of sensitized rats. In line with this issue, more investigations are necessary to uncover the therapeutic effect of CM administrated in repeated doses in comparison with single dose. Material and Methods: Male rats were divided into four experimental groups (n=6); control rats (C group), Sensitized rats (S group), sensitized rats received a single dose of 50 μl CM intravenously (S+SD group) and sensitized rats received repeated doses of 50 μl CM intravenously (S+SD group). Two weeks post-allergen challenge tracheal responsiveness to methacholine and pathological features were examined. Results: Our results showed that Tracheal responsiveness to methacholine and pathological scores in the lung tissue of asthmatic groups were significantly higher than the control rats (p<0.01 to p<0.001). CM in repeated dosages could significantly reduce Tracheal responsiveness and pathological injures in lung tissues (p < 0.001 to p < 0.05). In contrary, CM in single dosage did not yield any beneficial effect. Conclusion: Overall, this study showed that systemic administration of MSC-derived CM in repeated dosages, but not in single dose, could be effective in amelioration of asthmatic changes. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Final_Booklet.pdf | 1398/08/20 | 6876350 | دانلود |
| DSC_0331.JPG | 1398/08/20 | 2553865 | دانلود |
