| Background & objectives: Surgery of upper part of femor in elderly patients can be due to the
fracture of femoral neck, shaft and arthroplasty. Hemodynamic changes and complications of
the anesthesia are among the major concerns. The aim of this study was to compare the
hemodynamic changes in low dose isoflurane with propofol in upper femoral surgeries in
elderly patients.
Methods: This prospective clinical trial study was done on 60 patients over 65 year-old
elderly patients with ASA physical status of I and II that were candidate for upper femoral
surgery in two groups (inhalational: isoflurane 0.5-0.6 MAC) and (total intravenous
anesthesia with propofol 50-100 mic/kg/min). Hemodynamic changes were compared in these
groups with the same anesthetic depth (HR-SBP-DBP-MBP-SaO₂).
Results: There was no significant difference in heart rate, age or sex between two groups. In
isoflurane group SBP on 20 and 25th minutes and DBP and MBP on 20, 25 and 35th minutes
were significantly higher than propofol group. In propofol group SaO₂ was significantly more
than isoflurane group on induction, start of surgery and on 5, 25, 35 and 45th minutes of
surgery.
Conclusion: In anesthesia with the same Bi-Spectral Index, isoflurane provides more stable
hemodynamic parameters than propofol. |