چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Aim: Behcet’s disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا خبازی اسکویی | دهم |
| غلامرضا جدیداسلام | اول |
| خلیل انصارین | دوم |
| ابراهیم سخی نیا | سوم |
| زهره بابالو | چهارم |
| علیرضا ابهری | پنجم |
| شهریار علیپور | ششم |
| جعفر فرهادی | هفتم |
| سام صیدی شیروانی | هشتم |
| مرتضی قوجازاده | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Expression levels of miR-21, miR-146b and.pdf | 1398/08/16 | 658621 | دانلود |
