| خلاصه مقاله | Introduction: Breast cancer is the most common cancer type of women in many
countries. The survival rate of this cancer is increased by early diagnosis using
imaging methods and decision for appropriate treatment. For accurate diagnosis of
breast cancer, the imaging method should provide high sensitivity and specificity to
early detection of the lesions and avoid false positive results, respectively. Different
imaging modalities such as X-ray mammography, ultrasonography, magnetic
resonance imaging (MRI) and hybrid positron emission tomography/computed
tomography (PET/CT) have been used for diagnosis of breast cancer. The aim of this
study is review the role of PET/MRI as a novel bimodal imaging method for detection
and differentiation of breast cancer lesions.
Materials and methods: We reviewed the related published articles in Science Direct,
PubMed and Google Scholar using keywords such as breast cancer, PET/MRI,
sensitivity, specificity and diagnosis. Totally 29 articles were found and 11 of them
with the most relevance to our topic were reviewed.
Results: In hybrid PET/MRI, MRI provides high contrast morphological images of soft
tissue. Based on the diagnostic purpose, different techniques of MRI such as diffusion
or perfusion weighted imaging and dynamic contrast enhanced (DCE)-MRI are used
for cancer imaging. On the other hand, PET prepares important information about
metabolism of the tumor cells and status of the receptors. Radiation dose in PET/MRI
is lower than PET/CT as mainly used imaging method for evaluation of the
metastases.
Conclusion: Combination of MRI with a high sensitivity for detection of breast lesions
and PET with a high specificity for differentiation of malignant and benign lesions
introduces PET/MRI as a good candidate for high accuracy diagnosis of breast cancer. |