| DNA composite materials are at the forefront, especially for biomedical science, as they can increase the efficacy
and safety of current therapies and drug delivery systems. The specificity and predictability of the Watson-Crick
base pairing make DNA an excellent building material for the production of programmable and multifunctional
objects. In addition, the principle of nucleic acid hybridization can be applied to realize mobile nanostructures,
such as those reflected in DNA walkers that sort and collect cargo on DNA tracks, DNA robots performing tasks
within living cells and/or DNA tweezers as ultra-sensitive biosensors. In this review, we present the diversity of
dynamic DNA nanostructures functionalized with different biomolecules/functional units, imaging smart biomaterials capable of sensing, interacting, delivery and performing complex tasks within living cells/organisms. |