چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Objective To assess the effects of dietary vitamin D3on proinflammatory (interleukin-17A [IL-17A] and IL-6) and anti-inflammatory (IL-10) cytokines. Methods Our study was conducted on 75 participants who were divided into 3 groups: multiple sclerosis participants (MSPs, n = 25),first-degree relative participants (FDRPs, n = 25), and healthy participants (HPs, n = 25). All groups received 50,000 IU vitamin D3/wk for 8 weeks. Serum 25-(OH) vitamin D3 levels and messenger RNA (mRNA) expression levels of ILs were determined using electrochemiluminescence assay and real-time PCR, respectively. Results Vitamin D3affected the levels of IL-17A, IL-10, and IL-6 among the 3 groups (p< 0.001 for all). Levels of IL-17A (MSPs: fold change [FC] = 5.9,p= 0.014; FDRPs: FC = 5.2,p= 0.006; HPs: FC = 4.2,p= 0.012) and IL-6 (MSPs: FC = 5.6,p= 0.003; FDRPs: FC = 5.5,p= 0.002; HPs: FC = 5.1,p< 0.001) were downregulated after vitamin D3treatment. In addition, levels of IL-10 (MSPs: FC = 6.2,p= 0.005; FDRPs: FC = 4.6,p< 0.001; HPs: FC = 5.2,p< 0.001) were upregulated after 8 weeks. Conclusions Although supplementation with vitamin D3reduced the mRNA expression levels of IL-17A and IL-6, it increased the mRNA expression level of IL-10 in all groups. However, these effects were more considerable in the MSP group than in the other groups. Of interest, in a deficiency state of serum vitamin D3, IL-17A expression had a positive feedback effect on the expression of IL-6. Conversely, in the sufficient state, IL-10 expression had a negative feedback effect on the expression of IL-17A and IL-6. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رضا هاشمی | اول |
| محمد مرشدی | دوم |
| محمد اصغری جعفرآبادی | سوم |
| سید رفیع عارف حسینی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2018 Anti-inflammatory dietary vitaminD3.pdf | 1398/08/06 | 428769 | دانلود |
