چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مسعود نوری وسکه |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | بیماری های بافت همبند |
| کد مقاله | 69428 |
| عنوان فارسی مقاله | Comparison of Endoplasmic Reticulum Stress Markers in the Blood of Children and Young Patients with Cystic Fibrosis |
| عنوان لاتین مقاله | Comparison of Endoplasmic Reticulum Stress Markers in the Blood of Children and Young Patients with Cystic Fibrosis |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | 4th International Alavi Meeting |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tabriz |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/07/17 الی 1398/07/19 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://aria.tbzmed.ac.ir/News/18/%da%86%d9%87%d8%a7%d8%b1%d9%85%db%8c%d9%86-%d9%86%d8%b4%d8%b3%d8%aa-%d8%a8%db%8c%d9%86-%d8%a7% |
| آدرس علمی (Affiliation) نویسنده متقاضی | Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| مسعود نوری وسکه | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Cystic fibrosis (CF) grows dramatically by aging and in elder patients comorbidities with metabolic disease leading to worse health outcomes. However, activation of the unfolded protein response (UPR) in CF exhibits strong association between endoplasmic reticulum (ER) stress and CF population. Moreover, neutrophil dysfunction in CF is related to ER stress markers including GRP78 and ATF6 [1]. In this concept, it also has been demonstrated that ER stress contributes to CF through IRE1α-XBP1 signaling pathway [2]. Modulating ER stress markers exhibited beneficial effects in the symptoms of CF whereas attenuates inflammation and apoptosis [3]. Likewise, we are interested to find new biomarkers related to aging in which might be new tools for diagnosis and novel therapeutic agents via triggering the ER stress markers in the patients with imminent CF. Herein, evaluating levels of makers of ER stress including GRP78, ATF6, IRE1α, and XBP1 in the bloodstream of children and young patients with CF are the aim of this study. |
| کلمات کلیدی | Cystic Fibrosis; Endoplasmic Reticulum; Biomarker |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Cer.jpg | 1398/07/28 | 432117 | دانلود |
| CF.pdf | 1398/07/28 | 287144 | دانلود |
