| Vitamin D has been traditionally used as a mineral regulator in preventing musculoskeletal disorders. Nowadays, the beneficial effects of vitamin D on the skeletal system and several body organs have been identified. Recent studies have asserted that vitamin D contributes to the processes of anti-inflammatory and pro-inflammatory cytokines, as well as suppression of angiogenesis. The correlation between vitamin D level and several diseases has been investigated in numerous studies, however only a few have exactly considered the role of peripheral confounding factors on the levels of vitamin D. In the current letter, we aimed to define the important associated factors that should be taken into account in the determination of vitamin D deficiency in all patients and diseases in all regions. |