| The inflammatory efficacy of supplementation of natural nano-sized clinoptilolite (NCLN) and Nigella sativa
(NS) was evaluated At the end of 7th week in interleukin1β (IL1β), interleukin10 (IL-10), interleukin6 (IL-6) and
platelet (PLT), white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean
corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular
volume (MCV). 42 rats were divided into two groups as diabetic and non-diabetic. Diabetic group divided into 4
subgroups as normal control (NC), NS 1% food, NCLN 2%/food, NS 1%/food + NCLN 2%/food and fed high
fat diet (HFD) for 1 month, then injected 35mg/kg BW STZ to induce type 2 diabetes (T2D). Our results showed
IL-10 in NCLN and NCLN+NS groups were significantly higher NC group (p<0.05). IL-6 decreased in NS
group in comparison with DC group. And PLT decreased significantly in NCLN group in comparison with other
groups. Our data suggests NS and NCLN may have synergistic beneficial effects on increasing some of
anti-inflammatory factors. |