| Abstract
Background: Numerous studies have evaluated the
impact of Helicobacter pylori (H. pylori) eradication
on the number, severity, and recurrence of migraine
attacks. But the association of migraine, H. pylori, and
gastrointestinal (GI) presentation is challenging. The
aim of the current study was to investigate the
correlation between migraine, H. pylori, and peptic
ulcers among patients with dyspepsia undergoing
upper GI endoscopy.
Methods: 305 patients with dyspepsia referring to our
endoscopy ward, Shahid Beheshti Hospital affiliated to
Qom University of Medical Sciences, Qom, Iran, for
upper GI endoscopy filled out the study questionnaire. If
a patient was experiencing headaches and the migraine
was confirmed by neurologists, he/she was asked to
answer the questions related to migraine, which were
prepared exactly from Migraine Disability Assessment
(MIDAS) questionnaire. The relation between migraine
and confirmed H. pylori contamination was investigated
using statistical models.
Results: Of all the 305 patients, 133 (43.6%) had
confirmed episodic migraine headaches (MHs) and
177 patients (58.04%) had positive RUT for confirming
H. pylori contamination, of which 123 (69.5%) had
confirmed migraine. 52 (17.0%) had duodenal peptic
ulcer(s), of which, 49 (94.2%) had a positive rapid
urease test (RUT) (P < 0.001). 20 (6.5%) of all patients
had the gastric peptic ulcer(s) which did not have a
significant relation with H. pylori contamination. There
was a significant relationship between the peptic ulcer
site and migraine. In total, 177 patients (58.0%) had a
positive RUT. History of migraine was significantly
positive in those with positive H. Pylori contamination.
Notably, multivariable analysis demonstrated a
significant relation of H. pylori and migraine at
younger ages.
Conclusion: The prevalence of H. pylori and migraine
in patients with dyspepsia seems to be high.
Moreover, there is a meaningful association between
migraine, duodenal peptic ulcers, and H. pylori
infection, too. |