Phototoxicity of environmental radiations in human lens: revisiting the pathogenesis of UV-induced cataract
Phototoxicity of environmental radiations in human lens: revisiting the pathogenesis of UV-induced cataract
نویسندگان: فرزین کمری , شاهین حلاج , فاطمه درستی , فربد علی نژاد , نگار تلسچیان تبریزی , فرشته فرهادی , حسن اصلانی
کلمات کلیدی: Ultraviolet radiation . Cataracts . Lens . Pathophysiology . Oxidative stress . Crystallin . Tryptophan . Phototoxicity .
Cellular pathways . Protecting agents
نشریه: 13124 , 2019 , 257 , 2019
| نویسنده ثبت کننده مقاله |
حسن اصلانی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات سلامت و محیط زیست |
| کد مقاله |
69282 |
| عنوان فارسی مقاله |
Phototoxicity of environmental radiations in human lens: revisiting the pathogenesis of UV-induced cataract |
| عنوان لاتین مقاله |
Phototoxicity of environmental radiations in human lens: revisiting the pathogenesis of UV-induced cataract |
| ناشر |
7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
خیر |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| The magnitude of cataract pathology is indeed significant as it is the principal cause of blindness worldwide. Also, the prominence of this concept escalates with the current aging population. The burden of the disease is more tangible in developing
countries than developed ones. Regarding this concern, there is a gap in classifying the pathogenesis of the ultraviolet (UV)
radiation-induced cataracts and explaining the possible cellular and subcellular pathways. In this review, we aim to revisit the
effect of UVradiation on cataracts categorizing the cellular pathways involved. This may help for better pharmaceutical treatment
alternatives and their wide-reaching availability. Also, in the last section, we provide an overview of the protecting agents utilized
as UV shields. Further studies are required to enlighten new treatment modalities for UV radiation-induced pathologies in human
lens. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| UV induced cataract1.pdf | 1398/07/20 | 1975526 | دانلود |