چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Genome engineering technology is of great interest for biomedical research that enables scientists to make specific manipulation in the DNA sequence. Early methods for introducing double‐stranded DNA breaks relies on protein‐based systems. These platforms have enabled fascinating advances, but all are costly and time‐consuming to engineer, preventing these from gaining high‐throughput applications. The CRISPR‐Cas9 system, co‐opted from bacteria, has generated considerable excitement in gene targeting. In this review, we describe gene targeting techniques with an emphasis on recent strategies to improve the specificities of CRISPR‐Cas systems for nuclease and non‐nuclease applications. |
| نویسنده | نفر چندم مقاله |
|---|---|
| وحیده احمدزاده | اول |
| صفر فرج نیا | دوم |
| رقیه باغبان | سوم |
| لیلا رهبرنیا | چهارم |
| حبیب ذره دار | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ahmadzadeh final.pdf | 1398/07/17 | 1214813 | دانلود |
