چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: The key proliferative RTKs for AML include c-KIT receptor (CD117) and FLT-3 receptor (CD135). The aim of this study was to evaluate the CD135 and CD117 expression, co-expression of CD135 and CD117 (CD135+CD117), and the association of that co-expression with Event Free Survival (DFS) and Overall Survival (OS) rates. Material and Methods: We analyzed CD117 and CD135 expression on AML blasts by flow cytometry and its association with Event Free Survival (DFS) and Overall Survival (OS) in 66 AML treated on Hematology-Oncology Research Center, Iran, Tabriz. Results: The overall OS and EFS were 50% and 80.3% respectively during our study. Cox-regression analysis revealed that a poor EFS was signifcantly associated a low CD135 (HR 0.34, 95% CI 0.13–0.88, P = 0.02). Conclusion: This is the frst study from Iran to show that the expressions of CD135, CD117 is easily measurable by routine diagnostic flow-cytometry, and CD135+117 were not signifcantly associated with CR, EFS, or OS . |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا نیکانفر | دوم |
| بابک نجاتی | سوم |
| علی اکبر موثق پور اکبری | چهارم |
| رویا دولت خواه | پنجم |
| یوسف روستا | ششم |
| زهره صناعت | هفتم |
| مرتضی رئیسی | اول |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| APJCP_Volume 20_Issue 9_Pages 2625-2631.pdf | 1398/07/08 | 443803 | دانلود |
