چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| احد بازمانی | سوم |
| رسول جمالی | دوم |
| سانیا حیاتی لاله | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background: Visceral leishmaniasis (VL) is endemic in some areas of Iran, including Eas t Azerbaijan. However, mos t infections are subclinical or asymptomatic, reflecting the influence of hos t genetic background on disease outcome. CR1 is an immune regulatory protein that found on the surface of mos t leukocytes. This s tudy aimed to inves tigate association of CR1 polymorphism with protection agains t Visceral Leishmaniasis. Materials and Methods: Clarifying the effect of this SNP on Visceral Leishmaniasis, the s tudy was performed on 84 subjects with VL caused by Leishmania infantum as well as 75 seropositive and 93 seronegative controls without any his tory of leishmaniasis. Genotyping performed using polymerase chain reaction res triction fragment length polymorphism (PCR-RFLP) and electrophoresis on 3% agarose gel. Results: The frequency of the 3650A/A genotype of CR1 in the leishmaniasis patients (33, 39.3%) was significantly higher than that in the control groups (seropositive healthy 2, 2.7%, seronegative healthy 3, 3.2%). The frequency of the 3650G/G genotype of CR1 was significantly lower in the leishmaniasis patients (11, 13.1%) than that in the control groups (seropositive healthy 20, 26.7%, seronegative healthy 19, 20.4%). The results provide evidence of significant association between 3650A/G genotype and visceral leishmaniasis (VL) [odd ratio (OR) 1.24, 95% confidence interval (CI) 7.824-56.869, p value < 0.001]. Conclusion: These results sugges t that the 3650A/G genotype may lead to protection agains t visceral leishmaniasis. |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2 (1).jpg | 1398/07/07 | 97233 | دانلود |
| 2 (2).jpg | 1398/07/07 | 60118 | دانلود |
| 3.jpg | 1398/07/07 | 132269 | دانلود |
| first page.docx | 1398/07/15 | 196825 | دانلود |
| 1.docx | 1398/07/16 | 22654 | دانلود |
| 2.docx | 1398/07/16 | 22180 | دانلود |
| 1.docx | 1398/07/17 | 14492 | دانلود |
| 2.docx | 1398/07/17 | 16077 | دانلود |
