| Introduction: Solubility of mineral trioxide aggregate (MTA) is an important characteristic
that affects other properties such as microleakage and biocompatibility. Distilled water (DW)
has previously been used for solubility tests. This experimental study compared the solubility
of MTA in DW, synthetic tissue fluid (STF) and new simulated plasma (SP). Methods and
Materials: In this study, 36 samples of tooth-colored ProRoot MTA were prepared and
divided into three groups (n=12) to be immersed in three different solutions (DW, STF, and
SP). Solubility tests were conducted at 2, 5, 9, 14, 21, 30, 50, and 78-day intervals. The
unequal variance F-test (Welch test) was utilized to determine the effect of solubility media
and Games-Howell analysis was used for pairwise comparisons. The repeated-measures
ANOVA was used to assess the importance of immersion duration. Results: Welch test
showed significant differences in solubility rates of samples between all the different solubility
media at all the study intervals (P<0.05) except for the 14-day interval (P=0.094). The mixed
repeated-measures ANOVA revealed a significant difference in solubility rate of MTA in
three different solutions at all time-intervals (P=0.000). Games-Howell post-hoc test revealed
that all pairwise comparisons were statistically significant at all time-intervals (P=0.000).
Conclusion: Based on the findings of this study, the long-term solubility of MTA in
simulated plasma was less than that in synthetic tissue fluid and distilled water |