چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | نسترن هاشم زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | کمیته تحقیقات دانشجویی |
| کد مقاله | 69018 |
| عنوان فارسی مقاله | هدف درمانی سرطان سینه با استفاده از داروهای ایمنی و شیمی درمانی بارگذاری شده در نانوذرات مغناطیسی پوشش دهی شده با سیلیکای متخلخل |
| عنوان لاتین مقاله | TARGETED THERAPY OF BREAST CANCER USING IMMUNE CHEMO THERAPEUTIC AGENTS LOADED MESOPOROUS SILICA MAGNETIC NANOPARTICLES |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | Asian Federation for Medicinal Chemistry (AFMC) 12th International Symposium |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Turkey |
| شهر محل برگزاری کنگره/ همایش | Istanbul |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/06/17 الی 1398/06/20 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://aimecs2019.org/e-abstract-book |
| آدرس علمی (Affiliation) نویسنده متقاضی | 1) Department Of Pharmaceutics, Faculty Of Pharmacy, Tabriz University Of Medical Sciences, Tabriz, Iran 2) Biomedicine, Research Center For Pharmaceutical Nanotechnology, Tabriz University Of Medical Sciences, Tabriz, Iran 3) Students Research Committee, Faculty Of Pharmacy, Tabriz University Of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| نسترن هاشم زاده | اول |
| ژاله برار | دوم |
| خسرو ادیب کیا | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Over the last decades, due to the serious side effects associated with conventional chemotherapy agents targeted anticancer drug delivery has gained tremendous significance for cancer therapy. With the emergence of nanotechnology, fabricating a biocompatible, effective targeted delivery system is a major challenge for pharmaceutical science. More recently, the promise of immunotherapy in cancer therapy has resulted in the development of de novo treatment strategy. Tryptophan catabolism is considered as an important immunosuppressive pathway in tumor microenvironment. Indoleamine 2, 3-dioxygenase (IDO) catalyzes the destruction of tryptophan through the kynurenine pathway. Thus, inhibition of IDO is believed to effectively enhance anti-tumor immune response. Previous reports have demonstrated strong anti-cancer effects by combination of an Ido inhibitor with cytotoxic agent. Recently, Silica mesoporous magnetic nanoparticles (SMMNs) have achieved noteworthy attention as both therapeutic and theranostic agents. Due to their physicochemical advantages such as large and uniform pore size, SMMNs enjoy high surface area and silanol groups that can be replaced with other functionalities. As, there is widely held perception for methotrexate as chemotherapeutic agent in breast cancer. Herein we report on the fabrication of a drug delivery system in which the mesoporous silica magnetic nanoparticles carry IDO inhibitor agent along with Methotrexate into breast cancer cell lines. We use thermal decomposition process for synthesizing particles. In next step we used different analysis such as SEM, TEM, XRD, etc for characterizing synthesized particles.To determine cytotoxic effects of particles, we use co culture in Breast cancer cell lines and T cells. We believe that the targeted IDO inhibitor will improve restoring lymphocytes by inhibiting this enzyme in cancer cell lines. Also methotrexate will play a role as a chemotherapeutic agent in destruction of breast cancer cells. |
| کلمات کلیدی |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| document (12).pdf | 1398/06/30 | 4232787 | دانلود |
| AIMCS2019Abstract_book.pdf | 1398/06/30 | 12625137 | دانلود |
| 1.docx | 1398/07/02 | 14373 | دانلود |
| 2 (1).docx | 1398/07/02 | 15827 | دانلود |
