چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Temperature and cosolvent are themain parameters to change the aqueous solubility of chemicals and pharmaceuticals. Mathematical models and the parameters of solute and solvents are applied to predict and interpret their solubilization effects. In this study, the solubility of phenytoin in N-methylpyrrolidone (NMP)+watermixtureswas determined and the generated datawere correlatedwith the Jouyban-Acreemodel and its combination with Hansen solubility parameters and Abrahamsolvation parameters.Moreover, solubilization ratio of phenytoin in 10% of various cosolvents showed a considerable increase and a significant correlation between logarithm of solubilization ratio and hydrogen binding parameters was observed (R2 N 0.9). Despite NMP, temperature could not significantly increase the solubility of phenytoin in NMP + water mixtures against water. The results of this study indicated that NMP is a good solubilizing agent for phenytoin and applied mathematical models could predict solubility of phenytoin with a good accuracy in cosolvent + water mixtures. |
| نویسنده | نفر چندم مقاله |
|---|---|
| شیدا خجیر | اول |
| علی شایان فر | دوم |
| ابوالقاسم جویبان | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| J Mol liq 285 (2019) 58-61.pdf | 1398/06/22 | 352723 | دانلود |
