چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The equilibrium solubility at temperatures from (278.15 to 313.15) K, dissolution thermodynamics, preferential solvation, and apparent specific volume at saturation of sulfacetamide (SCM) in {ethanol (1) + water (2)} mixtures is reported. Mole fraction solubility of SCM(x3) increases when temperature arises and also increases with the ethanol proportion increasing reaching maximumvalues in the mixturew1=0.80. It varies from7.06× 10−4 in neatwater to 2.506 × 10−2 in themixturew1=0.80 at 298.15 K. Solubility behaviorwas adequately correlated by various cosolvency models and the obtained mean percentage deviations (MPD) varied between 2.6 and 15.9%. Moreover, the trained Jouyban-Acree model using a minimum number of 7 data points is used for predicting the rest of data points with the MPD of ~14% (N = 81). In addition, the generally trained model (Jouyban-Acree-Abraham) was also used to predict the solubility data of SCMin {ethanol (1)+water (2)} mixtures and obtained MPD for prediction was 36.9%. Fromthe variation of solubilitywith temperature the apparent thermodynamic analysis of dissolution was performed in all the mixtures and neat solvents. Based on the inverse Kirkwood-Buff integrals (IKBI) preferential solvation parameters were calculated. SCM is preferentially solvated by water molecules in water-rich mixtures and also in ethanol-rich mixtures. Further, from densities of the saturated solutions and those of the cosolvent mixtures free of drug, the apparent specific volumes at saturation were also calculated. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ابوالقاسم جویبان | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| J Mol Liq 290 (2019) 111219.pdf | 1398/06/22 | 1156838 | دانلود |
