| The solubility of minoxidil in the aqueous binary mixtures of ethanol at
different temperature are investigated and the obtained solubility data are
fitted by using some cosolvency models including van’t Hoff equation,
Yalkowsky model, Jouyban–Acree model and Jouyban–Acree–van’t Hoff
model. Themean relative deviations (MRD%) are used to illustrate themodels
performance. Moreover, the apparent entropy, enthalpy, and Gibbs free
energy of minoxidil dissolution process in the investigated solvent mixtures
are computed using van’t Hoff and Gibbs equations. Finally, by means of the
inverse Kirkwood–Buff integrals preferential solvation of minoxidil by water is
observed in water-rich and ethanol-rich mixtures. |