| DNA molecule engineering has become an attractive discipline in various research scopes. The profound influence
of selective and sensitive sensing of DNA molecules in disease diagnosis and molecular imaging is established.
In this perspective, we try to shed light on the state-of-the-art technology of DNA bioconjugation
assays in DNA biosensor, DNA barcode, DNA nanostructures, and DNA ultra-resolution fluorescence imaging.
Non-invasive, simple, and swift biotechniques benefit molecular diagnosis, evaluation of disease stages, and also
play a central role in fundamental researches. We discuss the limitations of traditional procedures and the
eminence impacts of the advanced methods with clinical applications in timely detection and management of
diseases like cancer, genetic disorders, and recognition of microbial pathogens. The predictable and programmable
DNA strands have paved the way for cellular and molecular imaging with the ability of single-molecule
switching nanoscopy. Consequently, the DNA conjugation tool as an identification paradigm of biological agents
in interaction with bio-spesific components is at the heart of biological processes. |