چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The maintenance of cytosolic pH in its physiological range is required for normal neuronal activity, and even minor alterations can have serious consequences. This Review summarizes the current understanding of the conditions that are associated with cytosolic pH disruption and that lead to abnormal cytosolic acidification. Oxidative stress results in cytosolic acidification, and this plays a crucial role in the emergence of apoptosis in protein misfolding and excitotoxicity, ultimately leading to irreversible neuronal damage. Through the identification of mechanisms by which intraneuronal pH acidification promotes neurodegeneration, we may identify new approaches for preventing and treating neurodegenerative disorders. © 2016 Wiley Periodicals, Inc. |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا مجدی | اول |
| جواد محمودی | دوم |
| سعید صدیق اعتقاد | سوم |
| صمد اسلام جمال گلزاری | چهارم |
| بابک صابرمعروف | پنجم |
| سیامک ریحانی راد | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| R-pH.pdf | 1398/06/20 | 478748 | دانلود |
