| Immunoinformatics is a new critical field with several tools and databases that conduct the
eyesight of experimental selection and facilitate analysis of the great amount of immunologic data obtained from experimental researches and helps to design and introducing new
hypothesis. Given these visages, immunoinformatics seems to be the way that develop and
progress the immunological research. Bioinformatics methods and applications are successfully employed in vaccine informatics to assist different sites of the preclinical, clinical, and
post-licensure vaccine enterprises. On the other hand, the progression of molecular biology
and immunology caused epitope vaccines have become the focus of research on molecular
vaccines. Moreover, reverse vaccinology could improve vaccine production and vaccination
protocols by in silico prediction of protein-vaccine candidates from genome sequences. Band T-cell immune epitopes could be predicted by immunoinformatics algorithms and computational methods to improve the vaccine design, protective immunity analysis, assessment
of vaccine safety and efficacy, and immunization modeling. This review aims to discuss the
power of computational approaches in vaccine design and their relevance to the development of effective vaccines. Furthermore, the various divisions of this field and available tools
in each item are introduced and reviewed. |