چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا قیاسی | دوم |
| صابر قادرپور | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Abstract ________________________________________ Introduction Type 2 diabetes is a metabolic disorder, which characterized by insulin resistance and a disturbance in the metabolism of lipids, carbohydrates, and hyperglycemia. recent studies have been recommended that defect and reduction of sirt1 (a nad-dependent class iii histone deacetylase) activity may be related with metabolic diseases such as atherosclerosis and t2dm. this study aimed to evaluate the effect of swimming training on the pancreatic level of sirt1 protein, metabolic conditions, and insulin sensitivity in type 2 diabetic male rats. Methods 28 male rats were allocated into four groups: control (con), exercise (exe), diabetes (dia) and diabetic exercise (dia- exe) (n=7). diabetes induced by a high-fat diet (hfd) for 4 weeks and a low dose of stz(35 mg/kg, ip). 7days after confirming of diabetes, the rats swam in the exercise groups for 12 weeks. at the end of the intervention and after the sedation with ketamine and xylazine, the blood samples and pancreatic tissue was prepared for biochemical measurements and pancreatic levels of sirt1 protein. Results This study indicated a significant decrease (p<0.01, p<0.05) in the pancreatic level of sirt1 protein and hdl, quiki (quantitative insulin sensitivity check index) and a significant disturbance (p<0.05) in the metabolic parameters (lipid profile and fbs). swimming training significantly (p<0.01, p<0.05) increased the pancreatic level of sirt1 protein and improved the metabolic parameters and insulin sensitivity. Conclusion These results suggested that swimming training by increasing the pancreatic level of sirt1 protein improved insulin sensitivity and metabolic disorder. these study findings suggested that the content of the expression of sirt1 in pancreatic tissue may be a promising novel therapeutic target for diabetic complications. |
| کلمات کلیدی | Diabetes; swimming training; sirt1; insulin sensitivity |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract . Congress.docx | 1398/05/30 | 16581 | دانلود |
| IMG_20190610_110533 (2).jpg | 1398/05/30 | 1308407 | دانلود |
