An overview of the myocardial regeneration potential of cardiac c-Kit+ progenitor cells via PI3K and MAPK signaling pathways
An overview of the myocardial regeneration potential of cardiac c-Kit+ progenitor cells via PI3K and MAPK signaling pathways
نویسندگان: بهناز ولی پور , راحله فرحزادی
کلمات کلیدی: Keywords: cardiac c-Kit+ progenitor cells • cardiac dysfunction • cardiomyocyte differentiation • cardiomyocyte
renewal • heart failure • MAPK/ERK signaling • mesenchymal stem cells • myocardial regeneration potential •
PI3K/Akt signaling • stem cell-based therapy
نشریه: 12370 , 3 , 16 , 2020
| نویسنده ثبت کننده مقاله |
راحله فرحزادی |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات قلب وعروق |
| کد مقاله |
68500 |
| عنوان فارسی مقاله |
An overview of the myocardial regeneration potential of cardiac c-Kit+ progenitor cells via PI3K and MAPK signaling pathways |
| عنوان لاتین مقاله |
An overview of the myocardial regeneration potential of cardiac c-Kit+ progenitor cells via PI3K and MAPK signaling pathways |
| ناشر |
4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
|
| نوع مقاله |
Review Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| In recent years, several studies have investigated cell transplantation as an innovative strategy to restore
cardiac function following heart failure. Previous studies have also shown cardiac progenitor cells as suitable
candidates for cardiac cell therapy compared with other stem cells. Cellular kit (c-kit) plays an important
role in the survival and migration of cardiac progenitor cells. Like other types of cells, in the heart,
cellular responses to various stimuli are mediated via coordinated pathways. Activation of c-kit+ cells
leads to subsequent activation of several downstream mediators such as PI3K and the MAPK pathways.
This review aims to outline current research findings on the role of PI3K/AKT and the MAPK pathways in
myocardial regeneration potential of c-kit+. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| fca-2018-0049.pdf | 1398/12/15 | 1473865 | دانلود |
