| Purpose: To assess the correlation of Tumor-Associated Tissue Eosinophilia (TATE) and blood eosinophil counts with tumor grade, size, and local lymph node involvement in oral squamous cell carcinoma.
Methods: In the present study, forty-three patients with a diagnosis of oral Squamous Cell Carcinoma (SCC) were evaluated. TATE was determined in ten random fields under ×40 magnification. Laboratory tests of the patients were also evaluated before surgery and repeated at three, six and twelve weeks after surgery. Data were analyzed by descriptive statistical methods (mean ± standard deviation), N (%) , repeated measures ANOVA, Pearson’s correlation coefficient and chi-square test. Statistical significance was defined at p<0.05.
Results: There was a correlation between TATE and tumor grade (p=0.03), but there wasn’t any correlation between TATE and tumor size or lymph node involvement. In the analysis of tumor-associated blood eosinophil counts, a correlation was observed with lymph node involvement (p= 0.02), but no correlation was noted with the tumor grade or size. In addition, peripheral blood analysis revealed that blood eosinophilia grades were significantly different one day before surgery from 6 and 12 weeks after surgery.
Conclusion: TATE was found to be associated with tumor grade , but not with tumor size or lymph node involvement. A correlation was observed with lymph node involvement, but no correlation was noted with the tumor grade or size. In addition, |