چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Among cancers, lung cancer is the most morbidity and mortality disease that is remaining the fatalist. Generally,there are multiple treatment procedures for lung cancer, such as surgery, immunotherapy, radiotherapy andchemotherapy. There is, therefore, an urgent need for more specified and efficient methods for treatment of lungcancer such as RNAi, which in combination with traditional therapies could silence genes that are involved in thedrug resistance. These genes may either be motivators of apoptosis inhibition, EMT and DNA repair systempromoters or a member of intracellular signaling pathways, such as JAK/STAT, RAS/RAF/MEK, PI3K/AKT,NICD, B-catenin/TCF/LEF and their stimulator receptors including IGFR, EGFR, FGFR, VEGFR, CXCR4, MET,INTEGRINS, NOTCH1 and FRIZZLED, so could be considered as appropriate targets. In current review, theresults of multiple studies which have employed drug application after one specific gene silencing or more thanone gene from distinct pathways also simultaneous drug and RNAi usagein vitroandin vivoin lung cancer weresummarized. |
| نویسنده | نفر چندم مقاله |
|---|---|
| بهزاد منصوری | چهاردهم |
| ساناز نقی زاده | اول |
| علی محمدی | دوم |
| بهزاد برادران | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1-s2.0-S0378111919306225-main.pdf | 1398/05/12 | 1190753 | دانلود |
