چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Bacillus Calmette–Guerin (BCG) is an established vaccine used for tuberculosis (TB) prevention;however,itisnoteffectiveinadults andisonlyprotective for children’s extrapulmonary TB. Therefore, many efforts have focused on producing effective TB vaccines for adults. One promising approach is DNA vaccination because of its ability to elicit both humoral and cellular immune responses, low cost, rapid production, desirable stability, and efficient protection against several infectious diseases. Nanoparticle (NP)-based systems can also enhance the immunogenicity of DNA vaccines by protecting naked plasmid DNA from nucleases and improving its delivery to immune cells. In this review, we focus on the design and delivery of novel DNA-based vaccines against TB and summarize investigations on specific mycobacterial antigens and chimeric combinations in animal models. |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر علی مختارزاده | سوم |
| بهزاد برادران | ششم |
| امیر باغبانزاده | هشتم |
| مریم حجازی | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| RecentprogressinthedesignofDNAvaccinesagainsttuberculosis.pdf | 1399/07/02 | 3022844 | دانلود |
