چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | بابک امامعلی زاده |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده پزشکی |
| کد مقاله | 68060 |
| عنوان فارسی مقاله | a bioinformatics approach to identify overlapping mirnas in autoimmune diseases |
| عنوان لاتین مقاله | a bioinformatics approach to identify overlapping mirnas in autoimmune diseases |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | دومین کنگره بین المللی زیست پزشکی |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1397 |
| سال انتشار/ارائه میلادی | 2018 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1397/10/03 الی 1397/10/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.icbcongress.com/2018/fa/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهسا طهماسبی وند | اول |
| زهرا بهمن پور | دوم |
| سید رضا موسوی | چهارم |
| یوسف دانشمندپور | ششم |
| بابک امامعلی زاده | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Introduction mirnas regulate gene expression and are important in pathological processes. disruption in mirnas expression may lead to dysregulation of immune conditions such as autoimmune responses. sjogrens syndrome (ss) as a common chronic autoimmune disease, is characterized by features such as dysfunction of exocrine organs, predominantly the salivary and lachrymal glands. sjogren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. the exact cause of the exocrine dysfunction in ss and these two similar diseases is not well understood. study of micrornas in a systemic autoimmune disease can make new advances in finding novel molecular diagnostic and prognostic biomarkers. recently, progresses in bioinformatics have been assisted to better understanding of the role of these regulatory factors. Methods To explore a novel mirna, the involving genes were obtained from disgenet database and common genes among ss and selected two related diseases identified by venn diagram. then mirnas that target these genes extracted from mirwalk database. in the next step, using the galaxy database, mirnas with highest number of targets among the common genes were recognized. Results Results indicate that hsa –mir-4433a, hsa-mir-6726, hsa-mir-423 regulate a significant number of genes, which can play a substantial and overlapping role in these three diseases. Conclusion Therefore, in this study, some novel and potential mirnas are introduced bioinformatically, which can be used for further experimental studies. |
| کلمات کلیدی | Bioinformatics approach, microrna (mirna), autoimmune disease, sjogrens syndrome |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| thumbnail (3).jpeg | 1398/04/31 | 119864 | دانلود |
| ICB2018Book.pdf | 1398/04/31 | 9606473 | دانلود |
