| Failure to thrive (FTT) is relatively common among cleft patients, most
common attributed to feeding problems during the 1st month of life. The close association
between midline clefts and pituitary gland abnormalities prompted us to determine the
frequency of growth hormone deficiency (GHD) in cleft patients, which is a preventable cause
of FTT and easily treated.
Any cleft patient with FTT was studied in a cross-sectional study and when the
patient’s height was under the 3rd percentile of normal, growth hormone was checked after
clonidine administration. Growth hormone was checked before and 30, 60, and 90 minutes
after clonidine use.
Of 670 patients with cleft lip or palate, 31 patients (4.0%) had some kind of growth
retardation according to weight, height, or head circumstance. 18 patients were under the 3rd
percentile of normal height. GHD was detected in 8 patients out of 18 patients and overall
frequency of GHD among cleft patients with growth retardation was 25.8% (8 out of 31). 7
patients of 8 were male, whereas one was female and half of the patients were syndromic.
Cleft patients have many problems with normal feeding, and all kind of support
should be provided to achieve near-normal feeding and they should be monitored for normal
growth. Any patient with growth retardation, especially height decrease, should be assessed
for growth hormone deficiency. |