| Metabolic syndrome is a common metabolic disorder which has become a public
health challenge worldwide. There has been growing interest in medications including
natural products as complementary or alternative choices for common chemical therapeutics
regarding their limited side effects and ease of access. Nanosizing these compounds may
help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This
study, for the first time, provides a comprehensive overview of the application of naturalproducts-
based nanoformulations in the management of metabolic syndrome. Different
phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin,
gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others
have been nanosized hitherto, and their nanosizing method and effect in treatment and
alleviating metabolic syndrome have been reviewed and discussed in this study. It has
been discovered that there are several pathways or molecular targets relevant to metabolic
disorders which are affected by these compounds. Various natural-based nanoformulations
have shown promising effect in treatment of metabolic syndrome, and therefore can be
considered as future candidates instead of or in conjunction with pharmaceutical drugs if
they pass clinical trials successfully. |