چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Since the discovery of the histamine H3 receptor in 1983, tremendous advances in the pharmacological aspects of H3 receptor antagonists/inverse agonists have been accomplished in preclinical studies. At present, there are several drug candidates that reached clinical trial studies for various indications. However, entrance of these candidates to the pharmaceutical market is not free fromchallenges, and a variety of difficulties is engaged with their developmental process. In this review, the potential role ofH3 receptors in the pathophysiology of various central nervous system, metabolic and allergic diseases is discussed. Thereafter, the current status for H3 receptor antagonists/ inverse agonists in ongoing clinical trial studies is reviewed and obstacles in developing these agents are emphasized |
| نویسنده | نفر چندم مقاله |
|---|---|
| نکیسا قمری | اول |
| سیاوش دستمالچی | پنجم |
| مریم حمزه میوه رود | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Ghamari_review_2019.pdf | 1398/04/25 | 1590670 | دانلود |
