چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | امیر فتاحی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 67926 |
| عنوان فارسی مقاله | Free 25(OH)-vitamin D and vitamin D binding protein are potential biomarkers for leiomyoma and are associated with the leiomyomas size |
| عنوان لاتین مقاله | Free 25(OH)-vitamin D and vitamin D binding protein are potential biomarkers for leiomyoma and are associated with the leiomyomas size |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | European Society of Human Reproduction and Embryology 2019 |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Austria |
| شهر محل برگزاری کنگره/ همایش | Vienna |
| سال انتشار/ ارائه شمسی | 1398 |
| سال انتشار/ارائه میلادی | 2019 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1398/04/02 الی 1398/04/05 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://www.eshre.eu/ESHRE2019/Programme/Searchable#!abstractdetails/0000586030 |
| آدرس علمی (Affiliation) نویسنده متقاضی | Tabriz University of Medical Sciences, Department of Reproductive Biology, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر فتاحی | اول |
| زینب لطیفی | دوم |
| حمیدرضا نجابتی | پنجم |
| محمد نوری | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Study question: Are there associations between serum levels of vitamin D binding protein (DBP) and free 25(OH)-vitamin D with leiomyoma and the lesions characteristics? Summary answer: Free 25(OH)-vitamin D and DBP had respectively positive and negative correlations with the leiomyomas size and could be potential biomarkers for leiomyoma. What is known already: Role of vitamin D particularly its free form and also DBP as the modulator has been demonstrated in tumor progression. Moreover, the association of the blood levels of total vitamin D with the prevalence of uterine leiomyoma has been reported. Furthermore, the inhibitory effect of vitamin D on leiomyoma formation and progression has been documented. Previous studies also showed significantly lower and higher levels of respectively vitamin D and DBP in the blood of women with leiomyoma compared to healthy subjects. Study design, size, duration: Leiomyoma was diagnosed using transabdominal ultrasound screening and confirmed by histological analysis. In the patients, the number, size and location (Intramural, Subserosal, Transmural, Submucosal, Intramural- Subserosal, and Intramural- Submucosal) of the leiomyomas were determined. Participants/materials, setting, methods: Forty-four leiomyoma patients aged 35.32±6.15 and forty-one healthy women with age of 32.69±6.44 were enrolled in this study. In all the participants, serum levels of total 25(OH)-vitamin D and DBP were measured using commercial ELISA kits. Furthermore, serum levels of 25(OH)-vitamin D/DPB ratio and free 25(OH)-vitamin D were calculated. Main results and the role of chance: Levels of 25(OH)-vitamin D/DPB ratio and free 25(OH)-vitamin D were significantly lower in patients group compared to the controls (p<0.001). We also found statistically higher levels of DBP in the patient with leiomyoma in comparison with the healthy women (p<0.001). There was no significant association between the evaluated serum factors with the location and number of the leiomyomas (p>0.05). However, the size of the largest leiomyomas had negative correlations with 25(OH)-vitamin D/DPB ratio and free 25(OH)-vitamin D levels and a positive correlation with DBP. Based on receiver operating characteristic (ROC) analyses, cutoff values for free 25(OH)-vitamin D and DBP as markers for leiomyoma diagnosis were 4.36 (pg/ml) and 251.7 (µg/ml) with sensitivity 78% and 88% and specificity of 76.7% and 71%, respectively. Limitations, reasons for caution: Our study had a relatively small sample size. Wider implications of the findings: Free 25(OH)-vitamin D and DBP had a role in leiomyoma pathogenesis and were associated with the size of leiomyomas. Serum levels of these factors can be used as biomarkers for the leiomyoma diagnosis. Trial registration number: not applicable |
| کلمات کلیدی | Leiomyoma Vitamin D vitamin D binding protein uterine fibroid |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Abstract 2019.pdf | 1398/05/11 | 73048 | دانلود |
| presentation certificate.pdf | 1398/05/11 | 205626 | دانلود |
| Attendance certificate.pdf | 1398/05/11 | 242412 | دانلود |
