تاثیر وانادیوم بر مارکرهای بیوشیمیایی التهابی و استرس اکسیداتیو در دیابت: مرور نظاممند مطالعات حیوانی
The effects of Vanadium on biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies
مجریان: مریم ثقفی اصل
خلاصه روش اجرا: In the current systematic review, the guidelines for systematic review of animal experiments and Preferred Reporting Items for Systematic Reviews (PRISMA) were applied. All PRISMA-compliant searches of PubMed, Scopus, and Web of Science, since 1990 up to 2021 were performed for animal studies assessing the effect of vanadium compounds supplementation on biomarkers of inflammation and oxidative stress in diabetes-induced animals. Studies accomplished on lesion-induced animals, samples with alternative diets, samples with pregnant females or samples with surgical interventions or invasive procedures, will be excluded. Two investigators will independently screen all the studies based on the eligibility criteria. Also, two authors will independently extract the following data using a pre-standardized data extraction form, which includes the authors, publication year, randomization, sample size, population, species, mean weight, compound, dosage, usage, and length of intervention. The extracted data will be rechecked by a third author. In order to assess risk of bias of the included studies, the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE)’s Risk of Bias tool will be used. The following outcomes regarding the therapeutic effects of different vanadium compounds will be predefined and extracted from the included animal studies. Inflammatory biomarkers such as Tumour Necrosis Factor alpha (TNF-α), Interleukin 6 (Il-6), high-sensitivity C-reactive protein (hs-CRP), Caspase 3 and oxidative stress biomarkers such as Malondialdehyde (MDA), Glutathione (GSH), Lipid peroxidation (LPO), SOD, CAT, TBARS, Nitric oxide (NO), 4-Hydroxynonenal (4-HNE), GPx, Glutathione S-transferase (GST) and GSR (qualitative description).
اطلاعات کلی طرح 
| مرحله جاری طرح | خاتمه قرارداد و اجرا |
| کد طرح | 67836 |
| عنوان فارسی طرح | تاثیر وانادیوم بر مارکرهای بیوشیمیایی التهابی و استرس اکسیداتیو در دیابت: مرور نظاممند مطالعات حیوانی |
| عنوان لاتین طرح | The effects of Vanadium on biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies |
| نوع طرح | طرح تحقیقاتی |
| اولویت طرح | تغذیه درمانی پزشکی در بیماریهای مزمن و غیرواگیر |
| نوع مطالعه | مطالعات مرور سیستماتیک |
| تحقیق در نظام سلامت | بلی |
| آیا طرح پایاننامه دانشجویی است؟ | خير |
| مقطع پایان نامه | دکتری تخصصی PhD |
| مدت اجرا - ماه | 5 |
| نوآوری و ضرورت انجام تحقیق | Diabetes mellitus (DM), as the most common endocrine disorder of the decade, is characterized by hyperglycemia and long-term complications affecting the eyes (retinopathy), kidneys (nephropathy), nerves (neuropathy), liver, and blood vessels (1). In 2016, according to the International Diabetes Federation report, approximately 425 million people around the world were diagnosed with diabetes and it is estimated that this number will reach to 629 million by the end of 2045 (2). Type 1 diabetes (T1DM), representing 5–10% of the total cases of diabetes, is defined as an autoimmune condition that leads to the destruction of pancreatic cells due to oxidative stress and apoptosis. On the contrary, type 2 diabetes (T2DM), representing nearby 95% of all cases, is characterized by decline in insulin secretion from β-cells, or insulin resistance (3). In type 2 diabetes, oxidative stress is enhanced due to overproduction of oxygen-free radicals and failure of the antioxidant defense system. Understanding the pathogenesis of diseases and ultimately, finding new therapies, is achieved through studying diabetes-induced animal models (4). In general, the imbalance between the generation and elimination of reactive oxygen species (ROS) due to oxidant formation is described as oxidative stress (3). In chronic hyperglycemia, auto-oxidation of glucose leads to the generation of oxidative stress and the production of free radical (5). Nevertheless, oxidative stress plays a key role in the onset and development of hyperglycemia. Biological antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and glutathione peroxidase (GPx) are few enzymes that directly scavenge free radicals or prevent their transformation to toxic derivatives (6). Increased oxygen-free radicals leads to lipid peroxidation of cellular lipids and production of lipid peroxidants (LPO) which is the main cause of microvascular complications of T2DM and atherosclerosis (7). Currently, insulin therapy and oral hypoglycemic drugs are the main treatment of diabetes. However, complications such as physical pain, anxiety, and cost-effectiveness are mentioned for long-time insulin therapy. Thus, seeking for complementary and effective supplements is crucial for diabetes management (8). Metal ions and their biomolecular complexes provide their beneficial effect by taking place in metalloproteins and metalloenzymes and affecting their gene expression, as well (9). Due to the beneficial actions of certain trace elements such as vanadium (V), boron (B), nickel (Ni), and silicon (Si), they are classified as ‘occasionally beneficial elements’ (10). Since 1970s, the hypoglycemic action of vanadium due to its insulin-mimetic or insulin-enhancer features has been discussed and gained the attention of researchers as a therapeutic agent against diabetes (11). Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidative balance of the organism. Vanadium as a scavenger of superoxide radicals decreases the activities of antioxidative activities of enzymes such as SOD, GPx, CAT, and GR in erythrocytes (12) (13-15), liver (8, 16-25), kidneys (8, 18, 23, 25), heart (25), brain (25, 26), pancreas (8, 20, 27), and testes (28) of rats. Based on the results of multiple studies, vanadium complexes increase the activity of GPx and demolish the effect of reactive oxygen species in diabetic-induced rats (6, 12, 25). Other studies claim that vanadyl sulphate supplementation protects rats from lipid peroxidation (16, 19, 25, 27, 29) and decreases levels of thiobarbituric acid reactive substances (TBARS) (10, 18, 21, 30, 31). The aim of this animal-based systematic review is to compile experimental evidence in order to provide an updated assessment of the effects of different vanadium compounds supplementation on biomarkers of inflammation and oxidative stress in diabetes. |
| اهداف اختصاصی | 1) Systematic review of the effect of vanadium on inflammation biomarkers in diabetes. -2) Systematic review of the effect of vanadium on oxidative stress biomarkers in diabetes. |
| چکیده انگلیسی طرح | Diabetes as one of the forth major non-communicable diseases that demands urgent attention from all shareholders globally in an effort to address its prevalence and associated complications. There is a strong link between hyperglycemia and hyperglycemic-induced oxidative stress and inflammation and the development and progression of diabetes mellitus type 2. Vanadium, as a transitional metal with redox properties, despite its insulin-mimetic and insulin-enhancing properties, enters the redox process, produces free radicals and distracts the pro-antioxidative balance of the organism. The purpose of the current animal systematic review is to evaluate the effect of different vanadium compounds administration on biomarkers of inflammation and oxidative stress in diabetic animals. This is, to our knowledge, the first systematic review of the literature with the aim of investigating the relationship between inflammation/oxidative stress and diabetes. Searches are performed in PubMed, Scopus, and web of science databases, since 1990 up to 2021 for animal studies examining the effect of vanadium on biomarkers of inflammation and oxidative stress in diabetic animals. |
| کلمات کلیدی | Diabetes mellitus (DM): DM is the most common endocrine disorder of the decade, is characterized by hyperglycemia and long-term complications affecting the eyes (retinopathy), kidneys (nephropathy), nerves (neuropathy), liver, and blood vessels Vanadium: Vanadium is a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidative balance of the organism. Oxidative stress: Oxidative stress is the imbalance between the generation and elimination of reactive oxygen species (ROS) due to oxidant formation. Systematic review: Systematic review is a type of review that use repeatable analytical methods to collect secondary data and analyse it. Inflammation: Inflammation is a localized physical condition in which part of the body becomes reddened, swollen, hot, and often painful, especially as a reaction to injury or infection. |
| ذینفعان نتایج طرح | Diabetic patients |
اطلاعات مجری و همکاران
| نام و نامخانوادگی | سمت در طرح |
|---|---|
| فائزه قالیچی | مجری دانشجویی(کمیته تحقیقات دانشجویی) |
| علیرضا استاد رحیمی | همکار اصلی |
| مریم ثقفی اصل | مجری اول (اصلی-هیات علمی) |
اطلاعات تفضیلی
| حوزه خبر | خبر |
|---|---|
| رسانه ها و مردم | عنوان خبر وانادیوم در کاهش التهاب و استرس اکسیداتیو در دیابت موثر است.متن خبر دیابت، شایع ترین اختلال اندوکرینی در دهه اخیر است. در حال حاضر، انسولین درمانی و داروهای کاهنده قند خون به عنوان درمان اصلی دیابت محسوب میشوند. وانادیوم به عنوان عنصری با قابلیت احیا و اکسیداسیون زنجیره انتقال الکترون از طریق تولید الکترونهای آزاد تعادل پیش آنتی اکسیدانی سلول را بهم میزند. نتایح مطالعات نشان میدهد که مکمل یاری طولانی مدت وانادیوم در کاهش استرس اکسیداتی و التهاب میتواند موثر باشد. |
| متخصصان و پژوهشگران | عنوان خبر متن خبر |
| سیاستگذاران درمانی | عنوان خبر متن خبر |
| سیاستگذاران پژوهشی | عنوان خبر متن خبر |
| لینک (URL) مقاله انگلیسی مرتبط منتشر شده 1 |
