| Background: Bloodstream infections are considered a significant medical concern associated
with high morbidity and mortality rates. Therefore, physicians should be guided to use
antimicrobial susceptibility patterns in order to select appropriate empiric antimicrobial agents
to treat the patients who suffer from bacteremia.
Objective: The present study aimed to determine antimicrobial resistance and susceptibility
patterns in isolates collected from bloodstream infections.
Materials and Methods: To achieve this, a total of 710 bacterial blood culture isolates were
collected from Sina hospital, and then susceptibility patterns to a number of antibiotics were
analyzed according to Clinical and Laboratory Standards Institute guidelines.
Results: The identified isolates included Staphylococcus aureus 14 (20.6%), Escherichia coli 14
(20.6%), Acinetobacter baumannii 12 (17.6%), Pseudomonas aeruginosa 11 (16.2%), Coagulasenegative Staphylococcus 8 (11.8%), Klebsiella pneumoniae 6 (8.8%), and Enterobacter spp.
3 (4.4%). The total resistance rate to co-trimoxazole, ceftriaxone, ceftazidime, cefotaxime,
ofloxacin, gentamicin, ciprofloxacin, levofloxacin, amikacin, and imipenem was 44 (64.7%),
42 (61.8%), 39 (57.4%), 38 (55.9%), 35 (51.51%), 32 (47.1%), 31 (45.6%), 25 (36.8%), and 27
(39.7%), respectively. Finally, the susceptibility rate to amikacin and imipenem was 43 (63.2%)
and 41 (60.3%), respectively.
Conclusion: In general, A. baumannii strains isolated from blood cultures were resistant to
most antibiotics and the greatest sensitivity was observed to gentamicin (58.3%) compared to
other antibiotics. Therefore, gentamicin was found as the most effective antibiotic for treating
bloodstream infections caused by A. baumannii. |