چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Alzheimer’s disease (AD) is the most common form of dementia in older population. Growing evidence of genetic background that predisposes individuals to AD has been reported as the risk factors in recent years. The Department of Medical Genetics and the Immunology Research Centre investigated the distribution of 11 polymorphisms in 160 patients with late onset AD (LOAD) and in 163 healthy controls, using the sequencing technique. All participants were of Turkish Azeri ethnicity. We compared allele and genotype frequencies between the LOAD patients and control subjects using a chi-square or Fisher’s exact test. Alleles and genotypes of APOE, PICALM rs3851179 and rs541458, and the BIN1 gene rs744373 polymorphism were significantly different between LOAD and control groups. The frequencies of the other investigated alleles were similar in the two groups. We also analyzed the association of BIN1, CR1 and PICALM SNPs with LOAD in subgroups stratified by the presence or absence of the APOE ε4 allele. After adjusting for APOE, statistical analysis revealed that the association with PICALM rs541458 and BIN1 rs744373 were only significant among subjects without the APOE ε4 allele. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم رضازاده | اول |
| جلال قره سوران | اول |
| عزیز خرمی | سوم |
| طرلان یگانه مرکید | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| GharesouranJ2014a.pdf | 1398/05/08 | 273540 | دانلود |
