چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Chemokines participate in the regulation of immune and inflammatory responses by interacting with their specific receptors on related immune and inflammatory cells such as B-lymphocytes, T-lymphocytes and antigen-presenting cells. Chemokines and their receptors are therefore considered to mediate inflammation and tissue damage in autoimmune disorders. The recent studies have revealed the genotypes of chemokine receptors (CCR) and their related polymorphisms in a number of autoimmune and infectious diseases. We used the polymorphic DNA markers (CCR2-64I) and (CCR5Δ32) to study the association of CCR2 and CCR5 gene mutations with Late-onset Alzheimer’s disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCRRFLP method and genotype frequencies were statistically determined. No significant linkage was determined between CCR5Δ32 and the disease of interest. However the gene CCR2 was appeared to be significantly linked to the disease, as it could be concluded from statistical analysis. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم رضازاده | دوم |
| سید مجتبی محدث اردبیلی | اول |
| جلال قره سوران | سوم |
| طرلان یگانه مرکید | چهارم |
| مهدی فرهودی | پنجم |
| هرمز آیرملو | ششم |
| مهناز طالبی | هفتم |
| مرتضی قوجازاده | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| ccr2, ccr5JSCIENCES_Volume 22_Issue 2_Pages 111-116.pdf | 1398/04/03 | 443582 | دانلود |
