چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| BACKGROUND: Recent findings suggest that production of pro-inflammatory cytokines, such as Tumour Necrosis Factor-alpha (TNF- α), is increased in the brain tissue of patients suffering late-onset Alzheimer’s disease (LOAD) and play an important role in the pathogenesis of this disease. Several epidemiological studies also suggest that patients taking anti-inflammatory drugs have a decreased risk of developing AD. TNF- α is an important pro inflammatory cytokine that is unregulated in Alzheimer’s patients. Functional polymorphisms in tumor necrosis factor alpha (TNF-α) can affect immune response, inflammation, tissue injury and possibly the susceptibility to Alzheimer disease (AD). METHODS: We used the polymorphic DNA markers (-308G/A) and (-863C/A) to study the association of TNF-α gene mutations with Late-onset Alzheimer’s disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and genotype frequencies were statistically determined. RESULTS: Our data showed significant difference in TNF-α-308 G/A genotype and pro inflammatory cytokine allele frequencies between the Alzheimer disease patients and healthy subjects. Contrary to that, no significant difference was observed in TNF-α-863 C/A genotype and allele frequencies between these two groups. CONCLUSIONS: TNF-α-308 G/A gene polymorphism could affect cerebral inflammatory response and the risk of lateonset Alzheimer disease but -863C/A polymorphism does not influence the risk of this disease and this possible association between TNF-α -308G/A and -863C/A gene polymorphisms have to be further elucidated in larger case control studies. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مریم رضازاده | چهاردهم |
| سید مجتبی محدث اردبیلی | اول |
| طرلان یگانه مرکید | دوم |
| جلال قره سوران | دوم |
| هرمز آیرملو | ششم |
| مهدی فرهودی | پنجم |
| مهناز طالبی | هفتم |
| مرتضی قوجازاده | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Mohaddes Ardebili et al, TNFa, 2011.pdf | 1398/04/04 | 156490 | دانلود |
