چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| is characterized by deficits in verbal and non-verbal communication, reciprocal social interactions, stereotypic behaviors, interests, and activities. During emberyonic brain development, Reelin provides signal for proper migration of newly generated postmitotic neurons. Since the Reelin plays a crucial role in these migratory processes. Therefore, reelin gene is considered as a potential candidate gene for autism. In this study, we aimed to investigate the probable association of this polymorphisms with autism spectrum disorder in Iranian-Azeri population. In this Case-control study, we recruited 74 patients with Autism spectrum disorder and 88 healthy controls. Genomic DNA isolated from blood leukocytes by the proteinase K and salting out method. SNP genotyping was carried out by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique. The collected data were analyzed through javastat online statistics software, using Chi-square (v2), with a significance level of 0.05. The allele and genotype frequencies did not show significant difference between cases and controls (p>0.05).Therefore, this SNPs could not be used as a useful molecular biomarker to predict genetic susceptibility for autism spectrum disorder in Iranian-Azeri patients. |
| نویسنده | نفر چندم مقاله |
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| حسن شاهرخی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| reelin.pdf | 1398/03/21 | 120897 | دانلود |
