چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Colorectal cancer (CRC) is the third most common cancer and a leading cause ofcancer‐related death worldwide. About 1.8 million new cases were reported in 2018.Accordingly, there is an urgent need for development of effective strategies to lowerthe mortality and morbidity originated from this malignancy. MicroRNAs (miRNAs)play key roles in several cellular events. They have attracted a great deal of attentionin the etiology of a variety of disorders including cancer and might be considered asdisease biomarkers or treatment targets. Initiation and development of CRC is amultistep process that is caused by loss of function (LOF) or gain of function (GOF) ingenes of different signaling pathways. Particular miRNAs conduct oncogenic impactsby suppressing their target transcripts and simulate the effects of LOF or GOF,whereas there may be no sign of common genetic or epigenetic modifications. On thecontrary, some miRNAs serve as tumor suppressor and help to maintain normalfunctioning and cellular homeostasis. Hence, highlighting the function of eachindividual miRNA in CRC tumorigenesis could assign it as a therapeutic target ormolecular marker for further investigations. In the present review, we have tried tocompile the latest information regarding the dysregulated miRNAs in CRC and theirfunction in different disease stages and signaling pathways involved. |
| نویسنده | نفر چندم مقاله |
|---|---|
| میلاد اسدی | سوم |
| مرتضی اکبری | چهارم |
| بهمن یوسفی | پنجم |
| داریوش شانه بندی | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Dysregulated microRNAs in colorectal carcinogenesis- New insight to cell survival and apoptosis regulation.pdf | 1398/03/18 | 1177044 | دانلود |
