چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| طاهره اعتراف اسکوئی | اول |
| عنوان | متن |
|---|---|
| کلمات کلیدی | Honey; TNF-a; Rat, Air Pouch, Rheumatoid Arthritis |
| خلاصه مقاله | Synthetic anti-inflammatory drugs have dangerous side effects which lead to research involved in identification of cheaper and safer alternatives from the natural resources. Honey is a natural product that is rich in carbohydrates, proteins, vitamins, trace elements, enzymes, and phenolic compounds. Honey for centuries has had a valued place in traditional medicine. Despite widespread research, honey has a limited use in modern medicine due to lack of scientific support. Because tumor necrosis factor alpha (TNF-a) as a key cytokine, can play a main role to regulate inflammation, the aim of present study was to investigate the effects of honey on the TNF-𝛼 concentration in a rat model for rheumatoid arthritis, namely air pouch model of inflammation. Male Wistar rats were anesthetized; 20 ml and 10 ml of sterile air were injected subcutaneously on the back on day 0 and day 3, respectively. On day 6, inflammation was induced by injection of 1 ml of carrageenan 1% -as a phlogistic agent- into pouches. One ml of honey (0.25, 0.5, 1 percent ) was administered intra pouch at the same time as the carrageenan and then for 2 consecutive days. The negative and positive control rats received saline and diclofenac sodium respectively. After 72h, the rats were sacrificed. The pouches fluid was collected and was centrifuged at 10000 g for 10 min to remove infiltrating leukocytes. The level of TNF-a was measured in supernatants using commercial ELISA kits. The concentration of TNF-a was significantly inhibited (P<0.05, P<0.01 & P<0.001) by honey with doses of 0.25, 0.5 & 1%, respectively. Interestingly, attenuation of TNF-a concentration by 1 % honey was similar to diclofenac sodium. The study confirms that honey has an inhibitory effect in the TNF-a production in the air pouch model of inflammation. Therefore, honey may be used to treat certain chronic inflammatory conditions. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| poster.pdf | 1398/03/25 | 4148472 | دانلود |
| Poster2.png | 1398/03/25 | 106871 | دانلود |
