چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| محمد سعید حجازی | چهارم |
| وحیده طرح ریز | اول |
| ام لیلا مولوی | سوم |
| عنوان | متن |
|---|---|
| کلمات کلیدی | CDK9, microRNAs, miR-1, myocardial differentiation |
| خلاصه مقاله | A major finding was the identification of key factors responsible for cardiac growth, namely a complex of proteins including Cdk9 and cyclin T1, which regulates by phosphorylation the activity of RNA polymerase II. On the other microRNAs (miRNAs) negatively regulate gene expression at the post-transcriptional level, primarily by base-pairing with the 3’-untranslated region (3’-UTR) of their target mRNAs . Many miRNAs are expressed in a tissue/organ-specific manner and are associated with an increasing number of cell proliferation, differentiation and tissue development events. Cardiac muscle expresses distinct genes encoding structural proteins and a subset of signal molecules that control tissue specification and differentiation. The transcriptional regulation of cardiomyocyte development has been well established, yet only until recently has it been uncovered that miRNAs participate in the regulatory networks. A subset of miRNAs are either specifically or highly expressed in cardiac muscle, providing an opportunity to understand how gene expression is controlled by miRNAs at the post-transcriptional level in this muscle type. MiR-1, miR-133, miR-206 and miR-208 have been found to be muscle-specific, and thus have been called myomiRs. MiR-1 microRNA expressed in cardiac and skeletal muscle has been found to exert crucial function(s) in their development and physiology. The Cdk9 transcript, a target of miR-1, shows sequence homology with the microRNA in the other hand overexpression of miR-1 in human cell lines leading to decrease the protein amounts of Cdk9 without affecting the mRNA levels, indicating that miR-1 post-transcriptionally inhibits Cdk9 translation. A highly attractive hypothesis is that also Cdk9 might be involved in cardiac microRNAs network regulation. In other word, Cdk9 may regulate miR-1 expression and miR-1 in turn targets Cdk9, thus forming a negative feedback loop. To test this hypothesis, Cdk9 is over expressed in C2C12 cells during cardiac differentiation. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| sokhanrani.pdf | 1398/03/09 | 2695649 | دانلود |
| sokhanrani-hamayesh ghalb.pdf | 1398/03/09 | 79703 | دانلود |
