چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Iron oxide magnetic nanoparticles (IoNps) have attracted enormous attention because of their extensive medicinal and industrial applicability. PEGylated L-arginine modifed iron oxide magnetic nanoparticles (peG-Arg@IoNps) were synthesized and functioned in the present research as MRI contrast agents considered in vivo BALB/c model. the synthesized peG-Arg@IoNps were tracked in certain time intervals by MRI. the intensity of MR imaging of kidneys increased after administration of PEG-Arg@IONPs, which could confrm the emission of these nanoparticles by kidneys shortly after administration. Although PEG-Arg@IONPs were uptake by liver within 2 hours after injection, whereas, the signal change intensity of spleen, heart and kidneys confrmed that PEG-Arg@IONPs existed in other organs. the results illustrated that IoNps coated with peGylated natural amino acid thin layers had a long circulation time and could be served as t2 contrast agents for diagnosis purpose. Notably, to the best of our knowledge, it was the frst time the biocompatibility and biodegradability of IONPs was studied and evaluated by stereological and MRI techniq |
| نویسنده | نفر چندم مقاله |
|---|---|
| سودابه داوران | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Nature.pdf | 1398/03/09 | 3158749 | دانلود |
