چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | عباس ابراهیمی کلان |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | دانشکده علوم نوین پزشکی |
| کد مقاله | 67099 |
| عنوان فارسی مقاله | بیان ژن CB1 در مدل حیوانی مالتیپل اسکلروزیس تحت درمان با hemp seed oil |
| عنوان لاتین مقاله | Expression of Cannabinoid Receptor 1 (CB1) in Animal Model of Multiple Sclerosis (EAE) Treated with Hemp Seed Oil |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | The 2nd International Neuroinflammation Congress and 2nd Student Festival of Neurosience |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1397 |
| سال انتشار/ارائه میلادی | 2018 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1397/03/09 الی 1397/03/12 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://shefayekhatam.ir/browse.php?a_id=1704&sid=1&slc_lang=en |
| آدرس علمی (Affiliation) نویسنده متقاضی | Department of Neurosciences and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; and Department of Radiology, School of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran, e-mail: ebrahimiab@tbzmed.ac.ir |
| نویسنده | نفر چندم مقاله |
|---|---|
| زینب علیاری سرج | سوم |
| عباس ابراهیمی کلان | پنجم |
| محمد پورحسن مقدم | ششم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Expression of Cannabinoid Receptor 1 (CB1) in Animal Model of Multiple Sclerosis (EAE) Treated with Hemp Seed Oil Multiple sclerosis (MS), as an auto-immune disease, is confined to the central nervous system and is usually accompanied with debilitating condition in MS patient. The rate of disease in the females is more than males (2:1), and it is diagnosed between 20 to 40 years old. Phototherapy, as a traditional remedy, is used to treat different pathological conditions including MS. Hemp seed oil, as an herbal drug, is used in this study to alleviate the symptoms EAE as an animal model of MS through alteration of the gene expression of Cannabinoid receptor 1. In this study 24 female C57bl/6 mice randomly divided into three groups: healthy group (group 1), Control group (group 2) and experimental group or hemp seed oil group (group 3). Immunization of all mice after one week acclimation in laboratory environment has been induced with Hooke kit except group 1. One day before of induction, feeding with hemp seed oil initiated and continues for 4 week in standard condition. Clinical score recorded daily through the study and in 28 days after immunization, all mice sacrificed after ketamine/xylazine anesthesia and spinal cord tissue removed for molecular and histopathological evaluation. Data analyzed with SPSS and ML win and P value <0.5 determined as significant. We observed significant differences in clinical scores between the control and experiment groups (p values < 0.001). Also, the expression of CB1 showed a statistically significant increase in the experiment group. In the present study, Hemp seed oil, due to its immunological effects, caused a decrease in the levels of inflammatory factors during the progress of multiple sclerosis in EAE animal model. Moreover, the clinical findings confirm the above result, showing a decrease in debilitating conditions of the disease. Therefore, administration of hemp seed oil alleviates the symptoms of the disease and it is useful for control of the inflammatory and auto-immune diseases. Nevertheless, it seems that additional research is needed to confirm the findings by clinical trials. |
| کلمات کلیدی | Multiple Sclerosis, EAE, CB1, Gene Expression, Hemp Seed Oil |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| The Neuroscience Journal of Shefaye Khatam-v6n2p205-en.pdf | 1398/03/07 | 256371 | دانلود |
| The Neuroscience Journal of Shefaye Khatam-v6n2p205-en.pdf | 1398/04/25 | 256371 | دانلود |
