چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | هانیه صالحی پورمهر |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات پزشکی مبتنی بر شواهد EBM |
| کد مقاله | 67096 |
| عنوان فارسی مقاله | purinergic signaling in neurogenic bladder after Spinal cord injury |
| عنوان لاتین مقاله | purinergic signaling in neurogenic bladder after Spinal cord injury |
| نوع ارائه | پوستر |
| عنوان کنگره / همایش | 6th Basic and Clinical neurosciences |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | Tehran |
| سال انتشار/ ارائه شمسی | 1396 |
| سال انتشار/ارائه میلادی | 2017 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1396/09/29 الی 1396/09/30 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://bcnc.ir/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | مرکز تحقیقات علوم اعصاب |
| نویسنده | نفر چندم مقاله |
|---|---|
| هانیه صالحی پورمهر | اول |
| نسرین ابوالحسن پور | دوم |
| سکینه حاج ابراهیمی | سوم |
| عباس ابراهیمی کلان | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background and Aim : Neurogenic bladder (NGB) and urinary incontinence is a common embarrassing condition in most of the neurological diseases like as Spinal Cord Injury (SCI). The prevalence of NGB in patients with SCI is 70% to 84%. Sacral micturition center (S2–S4), pontine micturition center, and cerebral cortex are responsible for normal urination cycle with facilitation and inhi¬bition of voiding. In SCI, the lesions between these pathways lead to losing normal bladder function with manifestation of neurogenic detrusor overactivity that exhibits as uninhibited bladder contraction and detrusor-sphincter- dyssinergia. Scientists discovered exocytotic vesicular release of ATP (a purine) as a co-transmitter with acetylcholine from parasympathetic neurons lead to bladder contraction and voiding reflex in many species. In healthy human the principal neurotransmitter that initiates muscle contraction is acetylcholine and the role of ATP is minor. However, in pathological conditions such as neurogenic bladder purinegic components increased to about 40% and its signaling (the binding of Adenosine triphosphate to its receptors) is introduced as a new pathway in pathogenesis of many types of NGB. Physiological roles of purinergic signaling in living bladder and urethra tissues consist of control of contraction/relaxation of mammalian bladder and relaxation of mammalian urethra. Beside it ATP plays a role in cell proliferation, differentiation, and death in development and regeneration, as well as in disease. ATP is a signaling molecule that can act as neurotransmitter and bind with 2 groups of receptors: ionotropic (P2X) and metabotropic (P2Y). P2X and P2Y receptors are present in urothelial cells. In both sensory transduction (by releasing ATP from the umbrella cells) and the function of bladder the purinergic signaling is play a critical role and is involved in numerous conditions like as spinal cord injury. The relationship between purinergic signaling and bladder function is demonstrated by knockout of P2X2/P2X3 in experimental models. After ATP release, P2X3 receptors on suburothelial sensory nerves initiate the voiding reflex and mediate the sensation of bladder filling and urgency. The other mechanism of ATP is its effect on suburothelial interstitial cells/myofibroblasts generating via Ca(2+) transient through gap junctions with sending signals from urothelium to detrusor muscle. Prolonged purinergic receptors activation leads to excitotoxicity and neurodegeneration. The results of immunohistochemistry staining of these receptors showed that P2X2 staining is stronger. And in animals study by using of A-317491 (as a selective P2X2/P2X3 purinergic receptor antagonist) showed a therapeutic effect in SCI developed overactive bladder by increasing the intervals of contractions. Beside it Brilliant blue G (P2X7 receptor antagonist) decrease astrocytes and microglia activation and lead to neuron protection from excitotoxicity and inflammatory responses. In SCI, ATP release is seen in response to mechanosensory cholinergic receptor activation followed by P2X7 receptor activation, hence inhibition of P2X7 receptors can improve SCI recovery by oxidizing ATP and PPADS and decrease in cell death. Also purinergic signaling affects bladder function in both central and peripheral (afferent and efferent components) nervous system. Beside it this signaling can altered smooth muscle of bladder and also urothelial. |
| کلمات کلیدی | Neurogenic bladder, purinergic signaling, Spinal Cord Injury |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2.1.pdf | 1399/05/31 | 5281527 | دانلود |
| 2.pdf | 1399/05/31 | 803602 | دانلود |
| BCNC (2).pdf | 1398/03/07 | 803602 | دانلود |
