| Background: Herbal rectal suppositories (RSs) were prescribed not only as a drug delivery system but also as a
storing method in Persian medicine. According to the record of ancient references, RSs were clinically
administered for diarrhea, constipation, colitis, ascites, dysentery and intestinal parasites, sciatic, lower back pain
and joint aches, fever, kidney disease and as an aphrodisiac. Objectives: The aim of this study is to categorize and
review different types of RSs, their main herbal components and to find evidence to elucidate their clinical
administration. Results: In this study, 7 manuscripts were studied to extract and categorize 11 types of herbal
rectal suppositorie (RS) formulations, their ingredients and therapeutic indications. Furthermore, the Persian and
scientific names of 43 herbs and their temperaments were mentioned in this study. Hence, ancient therapeutic
indications of herbs used in RS formulations as well as their proven effects have been studied, which makes it
possible to compare ancient and proven indications of medicinal plants used as ingredients of RSs. Conclusions:
In modern medicine, RSs are mostly used for anorectic disorders. However in traditional Persian medicine, they
were commonly used not only for anorectic and intestinal diseases, but also as an aphrodisiac, an agent for healing
joint, sciatic pain and lumbago, an anti-fever, and an anti-ascites. Other implications of this study could be
producing new insights of utilizing herbal RSs in diseases and disorders beyond anorectic and intestinal disorders. |